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Ointments




An ointment is a viscous semisolid preparation used topically on a variety of body surfaces. These include the skin and the mucous membranes of the eye (an eye ointment) and some more delicate parts of the body. An ointment may or may not be medicated.

The vehicle of an ointment is known as ointment base. The choice of a base depends upon the clinical indication for the ointment, and the different types of ointment bases are:

  1. Hydrocarbon bases e.g. hard paraffin, soft paraffin
  2. Absorption bases e.g. wool fat, beeswax
  3. Water soluble bases e.g. macrogols 200, 300, 400
  4. Emulsifying bases e.g. emulsifying wax, cetrimide
  5. Vegetable oils e.g. olive oil, arachis oil, coconut oil

The medicaments are dispersed in the base and later they get divided after the drug penetration into the living cells of skin.

Ointments are homogeneous, semi-solid preparations intended for external application to the skin or mucous membranes. They are used as emollients or for the application of active ingredients to the skin for protective, therapeutic, or prophylactic purposes and where a degree of occlusion is desired.

Ointments are formulated using hydrophobic, hydrophilic, or water-emulsifying bases to provide preparations that are immiscible, miscible, or emulsifiable with skin secretions. They can also be derived from hydrocarbon (fatty), absorption, water-removable, or water-soluble bases.

Methods of preparation of ointments

Trituration: In this finely subdivided insoluble medicaments are evenly distributed by grinding with a small amount of the base followed by dilution with gradually increasing amounts of the base.

Fusion: In this method the ingredients are melted together in descending order of their melting points and stirred to ensure homogeneity.




This article (which may be a derivative work resulting from the collaboration of multiple authors) is published under the terms of a Creative Commons Compatible Licence. Legal Stuff....

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